BRWD3

Across TCGA cell cohorts, BRWD3 mutation is significantly associated with the RNA expression of many other genes, with 1,732 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRWD3-associated genes across cancer lineages are PASK, METTL16, and QRICH2. Each is linked with BRWD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRWD3-to-partner and partner-to-BRWD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PASK grouped by BRWD3-low versus BRWD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRWD3→partner) and Y-score (partner→BRWD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PASK →	+0.780	+3.169	.001	.006	3	2
LARGE_INTESTINE	METTL16 →	+0.493	+2.043	.002	.008	3	2
LARGE_INTESTINE	QRICH2 →	+0.861	+2.043	<.001	.008	3	2
LARGE_INTESTINE	TRIM65 →	+0.483	+2.043	.007	.008	3	2
LARGE_INTESTINE	GATAD2B →	+0.570	+2.743	<.001	.001	3	2
LARGE_INTESTINE	FAM124A →	+0.695	+2.032	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,732 associations by consensus.

PASK by BRWD3 expression — LARGE_INTESTINE

Explore this box plot interactively →