Across TCGA pan-cancer cohorts, BRWD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BRWD1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BRWD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BRWD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where BRWD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.805	0.970	.005	22	view →
LUAD	DFS	Median	All	0.724	0.464	.013	19	view →
HNSC	OS	Quartile	All	0.780	0.930	.017	13	view →
UCEC	OS	Median	II,III,IV	1.000	0.647	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: BRWD1 tumor-vs-normal RNA expression · all BRWD1 data types