Across TCGA patient cohorts, BRWD1 mutation is significantly associated with the RNA expression of many other genes, with 5,399 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRWD1-associated genes across cancer lineages are TXNL4A, UQCR10, and ATP1B2. Each is linked with BRWD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRWD1-to-partner and partner-to-BRWD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRWD1→partner) and Y-score (partner→BRWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXNL4A →	+0.275	+1.457	.001	<.001	3	5
STAD	UQCR10 →	+0.488	+3.186	.007	.009	3	4
UCEC	ATP1B2 →	-0.621	-1.404	<.001	<.001	3	4
UCEC	UBR7 →	+0.580	+1.745	<.001	<.001	3	4
UCEC	CDCA2 →	+0.756	+1.841	<.001	<.001	3	4
UCEC	PBK →	+0.774	+1.702	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,399 associations by consensus.

Exploration

BRWD1 survival (RNA) · tumor vs normal (RNA) · all BRWD1 data types