BRSK2

Across TCGA patient cohorts, BRSK2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,826 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRSK2-associated genes across cancer lineages are PAK5, RELB, and ETHE1. Each is linked with BRSK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRSK2-to-partner and partner-to-BRSK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRSK2 versus PAK5 in GBM, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRSK2→partner) and Y-score (partner→BRSK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PAK5 →	+1.040	+0.518	<.001	<.001	3	2
GBM	RELB →	-0.562	-0.355	<.001	<.001	3	2
GBM	ETHE1 →	-0.353	-0.430	<.001	.005	3	2
GBM	AHR →	-1.222	-0.545	<.001	<.001	3	2
GBM	SLC1A2 →	+0.985	+0.359	.002	.004	3	2
GBM	PRMT8 →	+0.711	+0.555	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,826 associations by consensus.

BRSK2 vs PAK5 — GBM

Explore this scatter interactively →