BRSK2

Across TCGA patient cohorts, BRSK2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRSK2-associated genes across cancer lineages are Stathmin, 4E-BP1, and Cyclin-B1. Each is linked with BRSK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRSK2-to-partner and partner-to-BRSK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by BRSK2-low versus BRSK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRSK2→partner) and Y-score (partner→BRSK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.110	+1.662	.023	.011	3	2
UCEC	4E-BP1 →	+0.287	+2.000	.002	.003	3	2
UCEC	Cyclin-B1 →	+0.558	+2.222	.004	.010	3	2
COAD	Lck →	+0.450	+2.832	.007	.035	2	2
COAD	Smad4 →	+0.242	+2.815	<.001	.036	3	1
UCEC	14-3-3_beta →	-0.077	-1.847	.031	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Stathmin by BRSK2 expression — UCEC

Explore this box plot interactively →