BRSK1

Across TCGA patient cohorts, BRSK1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRSK1-associated genes across cancer lineages are Cyclin-B1, MSH2, and MSH6. Each is linked with BRSK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRSK1-to-partner and partner-to-BRSK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by BRSK1-low versus BRSK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRSK1→partner) and Y-score (partner→BRSK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.551	+3.000	.009	.034	3	2
UCEC	MSH2 →	-0.275	-1.848	<.001	.049	3	2
UCEC	MSH6 →	-0.253	-2.000	.029	.029	3	2
UCEC	Notch1 →	+0.135	+2.594	.006	.006	3	2
UCEC	p27_pT198 →	+0.075	+1.362	.048	.037	3	2
UCEC	ATM →	-0.540	-2.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Cyclin-B1 by BRSK1 expression — SKCM

Explore this box plot interactively →