BRSK1

Across TCGA cell cohorts, BRSK1 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRSK1-associated genes across cancer lineages are PAPOLB, BTNL2, and OR13C5. Each is linked with BRSK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRSK1-to-partner and partner-to-BRSK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAPOLB grouped by BRSK1-low versus BRSK1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRSK1→partner) and Y-score (partner→BRSK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PAPOLB →	+0.137	+4.510	<.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	BTNL2 →	+0.065	+4.209	.004	.006	3	2
URINARY_TRACT	OR13C5 →	+0.760	+5.087	<.001	.004	3	1
BLOOD_Leukemia	TPRX1 →	+0.021	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TMEM95 →	+0.028	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	OR10T2 →	+0.887	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

PAPOLB by BRSK1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →