BRS3

Across TCGA patient cohorts, BRS3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRS3-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1, and Cyclin-B1. Each is linked with BRS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRS3-to-partner and partner-to-BRS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by BRS3-low versus BRS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRS3→partner) and Y-score (partner→BRS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.235	+2.009	.037	.017	3	2
UCEC	4E-BP1 →	+0.203	+1.614	.030	.041	3	2
UCEC	Cyclin-B1 →	+0.607	+3.700	.001	.001	3	2
UCEC	INPP4B →	-0.253	-2.115	.024	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.139	-2.222	.017	.010	3	1
UCEC	JNK2 →	+0.160	+1.736	.020	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

p62 Lck ligand by BRS3 expression — UCEC

Explore this box plot interactively →