BRS3

Across TCGA cell cohorts, BRS3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRS3-associated genes across cancer lineages are ZP2, CLDN17, and TFDP3. Each is linked with BRS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRS3-to-partner and partner-to-BRS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZP2 grouped by BRS3-low versus BRS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRS3→partner) and Y-score (partner→BRS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZP2 →	+0.156	+3.678	<.001	.009	3	1
LARGE_INTESTINE	CLDN17 →	+0.052	+3.930	.001	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.037	+4.196	<.001	.002	3	1
LARGE_INTESTINE	CENPVL1 →	+0.182	+4.510	<.001	.001	3	1
LARGE_INTESTINE	NEXMIF →	+0.338	+4.196	<.001	.002	3	1
LARGE_INTESTINE	F11 →	+0.066	+4.882	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ZP2 by BRS3 expression — LARGE_INTESTINE

Explore this box plot interactively →