BRPF3

Across TCGA pan-cancer cohorts, BRPF3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BRPF3 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BRPF3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BRPF3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where BRPF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.552	1.000	.002	28	view →
CCRCC	DFS	Tertile	All	0.960	0.790	.030	13	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.435	.020	13	view →
HNSC	DFS	Median	II,III,IV	0.660	0.874	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BRPF3–UCEC (OS)

Open the UCEC breakdown →