BRPF3

Across TCGA patient cohorts, BRPF3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRPF3-associated genes across cancer lineages are PDCD4, ATM, and Caspase-7-cleavedD198. Each is linked with BRPF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRPF3-to-partner and partner-to-BRPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by BRPF3-low versus BRPF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRPF3→partner) and Y-score (partner→BRPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.467	-1.668	.002	.021	3	3
UCEC	ATM →	-0.671	-2.986	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.847	+2.267	<.001	<.001	3	3
UCEC	STAT3_pY705 →	-0.271	-1.652	.001	.006	3	2
UCEC	p53 →	-0.283	-2.584	.026	.010	3	2
UCEC	Shc_pY317 →	-0.195	-2.087	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PDCD4 by BRPF3 expression — UCEC

Explore this box plot interactively →