BRPF3

Across TCGA cell cohorts, BRPF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,195 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRPF3-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Transcription initiation-coupled chromatin remodeling, and Regulation of transcription initiation by RNA polymerase II. Each is linked with BRPF3 in more than 16 cancer types. Because this analysis shows association rather than direction, both BRPF3-to-partner and partner-to-BRPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by BRPF3-low versus BRPF3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRPF3→partner) and Y-score (partner→BRPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.075	+0.998	<.001	<.001	3	17
URINARY_TRACT	Transcription initiation-coupled chromatin remodeling →	+0.085	+1.049	<.001	<.001	3	16
BREAST	Regulation of transcription initiation by RNA polymerase II →	+0.063	+0.874	.002	<.001	3	16
BONE	Negative regulation of DNA-templated transcription initiation →	+0.163	+0.689	<.001	.001	3	16
BREAST	mRNA transcription by RNA polymerase II →	+0.079	+0.655	<.001	.003	3	16
BONE	Negative regulation of transcription initiation by RNA polymerase II →	+0.163	+0.689	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,195 associations by consensus.

Regulation of DNA-templated transcription initiation by BRPF3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →