BRPF3

Across TCGA cell cohorts, BRPF3 mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRPF3-associated genes across cancer lineages are N22899-6-C1, FGFR_0939, and Alisertib. Each is linked with BRPF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRPF3-to-partner and partner-to-BRPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N22899-6-C1 grouped by BRPF3-low versus BRPF3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRPF3→partner) and Y-score (partner→BRPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	N22899-6-C1 →	+0.345	+2.643	.007	.048	3	1
BLOOD_Leukemia	FGFR_0939 →	+0.401	+2.748	.003	.042	3	1
LARGE_INTESTINE	Alisertib →	+0.799	+2.646	.027	.047	3	1
LARGE_INTESTINE	NSC-207895 →	+0.496	+2.786	.021	.037	3	1
BLOOD_Leukemia	BAY-61-3606 →	+0.459	+2.889	.034	.025	2	1
LARGE_INTESTINE	IGF1R_3801 →	+0.614	+2.649	.041	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

N22899-6-C1 by BRPF3 expression — BLOOD_Leukemia

Explore this box plot interactively →