BRPF1

Across TCGA pan-cancer cohorts, BRPF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BRPF1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BRPF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BRPF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where BRPF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.772	0.933	.009	22	view →
HNSC	OS	Median	All	0.484	1.000	.038	14	view →
LSCC	DFS	Tertile	All	0.848	0.603	.022	13	view →
PDAC	DFS	Tertile	IV	0.934	0.199	.024	9	view →
CCRCC	DFS	Tertile	IV	0.908	0.173	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BRPF1–UCEC (DFS)

Open the UCEC breakdown →