BRPF1

Across TCGA patient cohorts, BRPF1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,961 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRPF1-associated genes across cancer lineages are ACVR2B, NPRL2, and PPM1D. Each is linked with BRPF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRPF1-to-partner and partner-to-BRPF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRPF1 versus ACVR2B in GBM, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRPF1→partner) and Y-score (partner→BRPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACVR2B →	+0.503	+0.204	<.001	<.001	3	5
BRCA	NPRL2 →	+0.583	+0.268	<.001	<.001	3	4
GBM	PPM1D →	+0.518	+0.260	<.001	<.001	3	4
HNSC	DUTP2 →	+1.006	+0.269	<.001	<.001	3	4
LSCC	TOP2B →	+0.591	+0.229	<.001	.001	3	4
BRCA	PXMP2 →	+0.516	+0.219	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,961 associations by consensus.

BRPF1 vs ACVR2B — GBM

Explore this scatter interactively →