BRPF1

Across TCGA cell cohorts, BRPF1 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRPF1-associated genes across cancer lineages are F11, TRIM51, and PRKACG. Each is linked with BRPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRPF1-to-partner and partner-to-BRPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F11 grouped by BRPF1-low versus BRPF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRPF1→partner) and Y-score (partner→BRPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	F11 →	+0.036	+3.204	<.001	<.001	3	2
URINARY_TRACT	TRIM51 →	+0.025	+4.217	.003	.005	3	1
URINARY_TRACT	PRKACG →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	RNASE9 →	+0.012	+4.087	<.001	.009	3	1
OESOPHAGUS	GLP1R →	+0.239	+4.392	.004	.003	3	1
OESOPHAGUS	KRTAP4-4 →	+0.330	+4.857	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

F11 by BRPF1 expression — LARGE_INTESTINE

Explore this box plot interactively →