BRMS1

Across TCGA patient cohorts, BRMS1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRMS1-associated genes across cancer lineages are GSK-3a-b_pS21_S9, STAT3_pY705, and ASNS. Each is linked with BRMS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRMS1-to-partner and partner-to-BRMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by BRMS1-low versus BRMS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRMS1→partner) and Y-score (partner→BRMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.575	+3.321	.010	.010	3	1
UCEC	STAT3_pY705 →	-0.438	-2.999	.001	.035	3	1
UCEC	ASNS →	+0.514	+2.999	.006	.035	3	1
UCEC	Akt_pT308 →	+0.877	+3.321	.007	.010	1	2
UCEC	Tuberin_pT1462 →	+0.490	+3.179	<.001	.010	2	1
UCEC	Tuberin →	+0.460	+3.321	.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GSK-3a-b_pS21_S9 by BRMS1 expression — UCEC

Explore this box plot interactively →