BRK1

Across TCGA pan-cancer cohorts, BRK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BRK1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher BRK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BRK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where BRK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.874	1.000	.009	78	view →
LUAD	OS	Median	All	0.938	0.982	.013	11	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	8	view →
HNSC	OS	Median	III,IV	1.000	0.449	.023	6	view →
CCRCC	DFS	Median	III,IV	0.774	0.207	.047	2	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BRK1–COAD (DFS)

Open the COAD breakdown →