BRK1

Across TCGA patient cohorts, BRK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,368 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible BRK1-associated proteins across cancer lineages are VGLL4, MKRN2, and UBE2J1. Each is linked with BRK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRK1-to-partner and partner-to-BRK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRK1 versus VGLL4 in BRCA, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BRK1→partner) and Y-score (partner→BRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VGLL4 →	+0.375	+0.356	<.001	.003	3	5
OV	MKRN2 →	+0.296	+0.399	<.001	.002	3	4
LSCC	UBE2J1 →	-0.738	-0.425	<.001	<.001	3	4
HNSC	SRP72 →	-0.228	-0.728	<.001	.007	3	4
LUAD	FNDC3A_S203 →	-0.454	-0.300	<.001	.001	3	4
LSCC	SPCS3 →	-0.773	-0.430	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,368 associations by consensus.

BRK1 vs VGLL4 — BRCA

Explore this scatter interactively →