BRK1

Across TCGA patient cohorts, BRK1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CESC shows the largest number of these associations.

The most reproducible BRK1-associated genes across cancer lineages are USP9YP2, OR2AT4, and MIR549A. Each is linked with BRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRK1-to-partner and partner-to-BRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP2 grouped by BRK1-low versus BRK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRK1→partner) and Y-score (partner→BRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	USP9YP2 →	+0.104	+8.066	<.001	.007	3	1
CESC	OR2AT4 →	+0.030	+4.969	<.001	.004	3	1
CESC	MIR549A →	+0.336	+5.342	<.001	.002	3	1
CESC	RNU1-82P →	+0.174	+5.144	<.001	.003	3	1
CESC	RN7SKP263 →	+0.123	+5.569	<.001	.002	3	1
CESC	DIAPH3-AS1 →	+0.204	+4.601	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

USP9YP2 by BRK1 expression — UCEC

Explore this box plot interactively →