BRK1

Across TCGA cell cohorts, BRK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,161 significant associations in total. CNS shows the largest number of these associations.

The most reproducible BRK1-associated GO terms across cancer lineages are tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, Positive regulation of pinocytosis, and Regulation of glycolytic process through fructose-6-phosphate. Each is linked with BRK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both BRK1-to-partner and partner-to-BRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation grouped by BRK1-low versus BRK1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRK1→partner) and Y-score (partner→BRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.162	+0.924	<.001	.004	3	12
CNS	Positive regulation of pinocytosis →	+0.087	+0.508	.003	.003	3	10
BREAST	Regulation of glycolytic process through fructose-6-phosphate →	+0.141	+1.132	<.001	<.001	3	10
BREAST	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.141	+1.132	<.001	<.001	3	10
BONE	Protein localization to early endosome →	+0.227	+0.465	<.001	.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of synapse structural plasticity →	+1.490	+0.999	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,161 associations by consensus.

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation by BRK1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →