BRIX1

Across TCGA patient cohorts, BRIX1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRIX1-associated genes across cancer lineages are ASNS, eIF4E, and FoxM1. Each is linked with BRIX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRIX1-to-partner and partner-to-BRIX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by BRIX1-low versus BRIX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRIX1→partner) and Y-score (partner→BRIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.457	+2.459	.002	.019	3	2
UCEC	eIF4E →	+0.197	+2.321	.023	.006	3	1
UCEC	FoxM1 →	+0.234	+2.321	.028	.006	3	1
UCEC	JNK2 →	+0.301	+3.000	<.001	.001	3	1
UCEC	Ku80 →	+0.233	+1.820	.017	.016	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.462	-1.794	.012	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ASNS by BRIX1 expression — UCEC

Explore this box plot interactively →