Across TCGA pan-cancer cohorts, BRI3P2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of BRI3P2’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where BRI3P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRI3P2 is over-expressed in tumor.
LUSC are the cancer types where BRI3P2 tumor–normal differential expression is most reproducible.