BRI3

Across TCGA pan-cancer cohorts, BRI3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BRI3 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher BRI3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BRI3 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

COAD, OV, and CCRCC are the cancer types where BRI3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.852	1.000	.010	72	view →
OV	DFS	Quartile	All	0.896	0.485	.032	8	view →
CCRCC	DFS	Median	All	0.736	0.869	.027	7	view →
LUAD	DFS	Median	II,III,IV	0.267	0.765	.028	2	view →
GBM	OS	Quartile	All	0.846	1.000	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BRI3–COAD (DFS)

Open the COAD breakdown →