BRI3

Across TCGA patient cohorts, BRI3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,056 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRI3-associated proteins across cancer lineages are PLOD3, PTPN12, and YWHAG. Each is linked with BRI3 in more than 6 cancer types. Because this analysis shows association rather than direction, both BRI3-to-partner and partner-to-BRI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRI3 versus PLOD3 in GBM, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BRI3→partner) and Y-score (partner→BRI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLOD3 →	+0.633	+0.381	<.001	<.001	3	7
GBM	PTPN12 →	+0.373	+0.330	<.001	<.001	3	6
OV	YWHAG →	+0.274	+0.387	.001	.001	3	6
COAD	RHEB →	+0.373	+0.373	.002	.001	3	5
GBM	PRSS23 →	+0.623	+0.340	<.001	<.001	3	4
LSCC	PTPN12_S332 →	+0.596	+0.459	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,056 associations by consensus.

BRI3 vs PLOD3 — GBM

Explore this scatter interactively →