BRI3

Across TCGA patient cohorts, BRI3 protein abundance is significantly associated with the RNA expression of many other genes, with 6,113 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRI3-associated genes across cancer lineages are CTSD, FTL, and HAUS6. Each is linked with BRI3 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRI3-to-partner and partner-to-BRI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRI3 versus CTSD in CCRCC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRI3→partner) and Y-score (partner→BRI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CTSD →	+0.621	+0.302	<.001	.001	3	4
LSCC	FTL →	+0.730	+0.429	<.001	.001	2	4
LSCC	HAUS6 →	-0.627	-0.324	.002	.001	3	3
LUAD	SAPCD2 →	-1.083	-0.570	<.001	<.001	3	3
UCEC	CDC6 →	-0.885	-0.481	.001	.002	3	3
GBM	ALOX5 →	+0.860	+0.264	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,113 associations by consensus.

BRI3 vs CTSD — CCRCC

Explore this scatter interactively →