BRI3

Across TCGA cell cohorts, BRI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,321 significant associations in total. CNS shows the largest number of these associations.

The most reproducible BRI3-associated GO terms across cancer lineages are Chromosomal 5-methylcytosine DNA demethylation pathway, 'de novo' IMP biosynthetic process, and DNA double-strand break processing. Each is linked with BRI3 in more than 11 cancer types. Because this analysis shows association rather than direction, both BRI3-to-partner and partner-to-BRI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosomal 5-methylcytosine DNA demethylation pathway grouped by BRI3-low versus BRI3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRI3→partner) and Y-score (partner→BRI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Chromosomal 5-methylcytosine DNA demethylation pathway →	-0.161	-0.659	.002	<.001	2	12
LARGE_INTESTINE	'de novo' IMP biosynthetic process →	-0.188	-1.049	<.001	<.001	3	11
STOMACH	DNA double-strand break processing →	-0.076	-1.736	<.001	<.001	3	11
OESOPHAGUS	Intracellular receptor signaling pathway →	+0.041	+1.009	.004	.006	3	11
UPPER_AERODIGESTIVE_TRACT	Lipid modification →	+0.045	+0.841	.001	.005	3	10
CNS	Membrane raft organization →	+0.134	+1.094	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,321 associations by consensus.

Chromosomal 5-methylcytosine DNA demethylation pathway by BRI3 expression — LARGE_INTESTINE

Explore this box plot interactively →