BRF2

Across TCGA patient cohorts, BRF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,121 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible BRF2-associated GO terms across cancer lineages are Positive regulation of DNA damage checkpoint, Regulation of chromosome condensation, and Transcription by RNA polymerase III. Each is linked with BRF2 in more than 29 cancer types. Because this analysis shows association rather than direction, both BRF2-to-partner and partner-to-BRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA damage checkpoint grouped by BRF2-low versus BRF2-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF2→partner) and Y-score (partner→BRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Positive regulation of DNA damage checkpoint →	+0.069	+0.604	<.001	<.001	3	30
DLBC	Regulation of chromosome condensation →	+0.098	+0.673	<.001	<.001	3	27
DLBC	Transcription by RNA polymerase III →	+0.042	+0.499	.005	.003	1	29
DLBC	Interstrand cross-link repair →	+0.064	+0.767	<.001	<.001	3	26
THYM	Maturation of LSU-rRNA →	+0.061	+1.171	<.001	<.001	3	26
DLBC	Neuronal stem cell population maintenance →	+0.053	+0.549	<.001	.001	2	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,121 associations by consensus.

Positive regulation of DNA damage checkpoint by BRF2 expression — DLBC

Explore this box plot interactively →