BRF2

Across TCGA patient cohorts, BRF2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,640 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRF2-associated genes across cancer lineages are BAG4, LSM1, and KLRG2. Each is linked with BRF2 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRF2-to-partner and partner-to-BRF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRF2 versus BAG4 in LSCC, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF2→partner) and Y-score (partner→BRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BAG4 →	+1.021	+0.877	<.001	<.001	3	5
LSCC	LSM1 →	+0.983	+0.918	<.001	<.001	3	4
HNSC	KLRG2 →	+1.329	+0.562	.006	<.001	3	3
HNSC	ETNK2 →	+1.092	+0.646	<.001	.004	3	3
HNSC	FNTA →	+0.559	+0.617	<.001	<.001	3	3
HNSC	POLB →	+0.885	+0.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,640 associations by consensus.

BRF2 vs BAG4 — LSCC

Explore this scatter interactively →