BRF2

Across TCGA patient cohorts, BRF2 protein abundance is significantly associated with the protein abundance of many other proteins, with 23,546 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BRF2-associated proteins across cancer lineages are ASH2L, NSD3, and BAG4. Each is linked with BRF2 in more than 4 cancer types. Because this analysis shows association rather than direction, both BRF2-to-partner and partner-to-BRF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BRF2 versus ASH2L in LSCC, with a Pearson correlation of 0.82.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF2→partner) and Y-score (partner→BRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASH2L →	+0.462	+0.874	<.001	<.001	3	5
LSCC	NSD3 →	+0.520	+0.919	<.001	<.001	3	5
BRCA	BAG4 →	+0.672	+0.938	.002	.004	2	5
BRCA	USP39 →	+0.271	+0.750	<.001	<.001	3	4
LSCC	NSD3_S150 →	+0.929	+0.819	<.001	<.001	3	4
BRCA	POLR1E →	+0.425	+0.893	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,546 associations by consensus.

BRF2 vs ASH2L — LSCC

Explore this scatter interactively →