BRF2

Across TCGA patient cohorts, BRF2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRF2-associated genes across cancer lineages are EGFR_pY1068, Ku80, and MEK1. Each is linked with BRF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRF2-to-partner and partner-to-BRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BRF2-low versus BRF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF2→partner) and Y-score (partner→BRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.246	-2.459	.042	.020	3	1
UCEC	Ku80 →	+0.265	+2.472	.020	.011	3	1
UCEC	MEK1 →	+0.476	+3.169	.007	.019	3	1
UCEC	mTOR_pS2448 →	-0.180	-2.980	.012	.036	2	1
UCEC	PCNA →	+0.282	+3.584	.006	.002	1	1
UCEC	PRDX1 →	+0.332	+2.459	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by BRF2 expression — UCEC

Explore this box plot interactively →