BRF2

Across TCGA cell cohorts, BRF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,758 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRF2-associated GO terms across cancer lineages are Protein-DNA complex assembly, DNA-templated transcription initiation, and Positive regulation of transcription by RNA polymerase III. Each is linked with BRF2 in more than 13 cancer types. Because this analysis shows association rather than direction, both BRF2-to-partner and partner-to-BRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex assembly grouped by BRF2-low versus BRF2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF2→partner) and Y-score (partner→BRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein-DNA complex assembly →	+0.091	+0.801	<.001	.003	2	14
LUNG_NSCLC_LUSC	DNA-templated transcription initiation →	+0.064	+1.307	.002	.001	3	12
BLOOD_Myeloma	Positive regulation of transcription by RNA polymerase III →	+0.110	+1.225	<.001	.001	2	12
LUNG_SCLC	Transcription preinitiation complex assembly →	+0.072	+0.843	<.001	.002	3	11
STOMACH	tRNA transcription by RNA polymerase III →	+0.108	+0.775	<.001	.006	1	12
BONE	Protein-DNA complex organization →	+0.096	+0.753	<.001	.004	1	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,758 associations by consensus.

Protein-DNA complex assembly by BRF2 expression — BONE

Explore this box plot interactively →