Across TCGA pan-cancer cohorts, BRF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BRF1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher BRF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BRF1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

GBM, CCRCC, and LSCC are the cancer types where BRF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.487	0.243	<.001	18	view →
CCRCC	DFS	Median	All	0.919	0.558	.013	5	view →
LSCC	OS	Quartile	II,III,IV	0.822	0.540	.034	3	view →
PDAC	DFS	Tertile	II,III,IV	0.431	0.308	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: BRF1 tumor-vs-normal RNA expression · all BRF1 data types