Across TCGA patient cohorts, BRF1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,927 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BRF1-associated genes across cancer lineages are MLH3, SNHG10, and ALKBH1. Each is linked with BRF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both BRF1-to-partner and partner-to-BRF1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF1→partner) and Y-score (partner→BRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MLH3 →	+0.467	+0.321	<.001	.001	3	7
LSCC	SNHG10 →	+0.576	+0.355	<.001	<.001	3	6
CCRCC	ALKBH1 →	+0.419	+0.208	<.001	.009	3	6
LSCC	TRIP11 →	+0.455	+0.416	<.001	<.001	3	6
HNSC	NEK9 →	+0.469	+0.255	.001	.008	3	6
LUAD	CLBA1 →	+0.647	+0.253	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,927 associations by consensus.

Exploration

BRF1 survival (RNA) · tumor vs normal (RNA) · all BRF1 data types