Across TCGA patient cohorts, BRF1 mutation is significantly associated with the RNA expression of many other genes, with 2,017 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRF1-associated genes across cancer lineages are ZNF519P1, LINC02500, and MIR3908. Each is linked with BRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRF1-to-partner and partner-to-BRF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF1→partner) and Y-score (partner→BRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ZNF519P1 →	+0.016	+4.144	<.001	.009	3	2
CESC	LINC02500 →	+0.657	+4.144	<.001	.009	3	2
CESC	MIR3908 →	+0.243	+3.760	<.001	.004	3	2
CESC	NF1P10 →	+0.133	+5.569	<.001	<.001	3	2
UCEC	GNPNAT1 →	+0.591	+2.332	<.001	<.001	3	2
UCEC	DOT1L →	+0.475	+1.658	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,017 associations by consensus.

Exploration

BRF1 survival (RNA) · tumor vs normal (RNA) · all BRF1 data types