Across TCGA patient cohorts, BRF1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRF1-associated genes across cancer lineages are JNK_pT183_Y185, MSH2, and MSH6. Each is linked with BRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRF1-to-partner and partner-to-BRF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF1→partner) and Y-score (partner→BRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.171	-2.247	.001	.001	3	2
UCEC	MSH2 →	-0.328	-2.558	<.001	<.001	3	2
UCEC	MSH6 →	-0.350	-2.502	<.001	.001	3	2
UCEC	Notch1 →	+0.142	+1.820	.001	.014	3	2
UCEC	Akt_pT308 →	+0.441	+1.700	.028	.040	3	2
UCEC	Annexin-1 →	+0.485	+1.906	.003	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

BRF1 survival (RNA) · tumor vs normal (RNA) · all BRF1 data types