Across TCGA cell cohorts, BRF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,839 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRF1-associated GO terms across cancer lineages are Regulation of protein localization to endoplasmic reticulum, Negative regulation of calcium ion export across plasma membrane, and tRNA transcription. Each is linked with BRF1 in more than 16 cancer types. Because this analysis shows association rather than direction, both BRF1-to-partner and partner-to-BRF1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF1→partner) and Y-score (partner→BRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of protein localization to endoplasmic reticulum →	+0.134	+1.056	<.001	.001	3	17
SOFT_TISSUE	Negative regulation of calcium ion export across plasma membrane →	+0.077	+1.214	<.001	<.001	3	17
URINARY_TRACT	tRNA transcription →	+0.129	+0.883	<.001	<.001	3	17
BONE	Positive regulation of protein autoubiquitination →	+0.244	+1.019	<.001	<.001	3	16
OESOPHAGUS	Negative regulation of RNA splicing →	+0.092	+0.697	<.001	<.001	3	16
OESOPHAGUS	Negative regulation of mRNA splicing, via spliceosome →	+0.103	+0.743	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,839 associations by consensus.

Exploration

BRF1 survival (RNA) · tumor vs normal (RNA) · all BRF1 data types