Across TCGA cell cohorts, BRF1 mutation is significantly associated with the RNA expression of many other genes, with 488 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRF1-associated genes across cancer lineages are PGK2, CCL23, and C12orf40. Each is linked with BRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRF1-to-partner and partner-to-BRF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRF1→partner) and Y-score (partner→BRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
BREAST	CCL23 →	+0.044	+5.169	<.001	.005	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
OVARY	USP17L13 →	+0.010	+4.807	<.001	.003	3	1
OVARY	USP17L17 →	+0.010	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 488 associations by consensus.

Exploration

BRF1 survival (RNA) · tumor vs normal (RNA) · all BRF1 data types