BRDT

Across TCGA pan-cancer cohorts, BRDT Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BRDT data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BRDT Mutation is associated with better overall survival. In most high-consensus cancer types, elevated BRDT expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BLCA, and ESCA are the cancer types where BRDT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.453	.005	36	view →
BLCA	OS	Median	IV	0.086	0.605	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
LUSC	OS	Median	II,III,IV	0.188	0.421	.011	6	view →
BRCA	OS	Median	All	0.877	0.963	.045	2	view →
COAD	OS	Median	All	0.598	0.872	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BRDT–UCEC (OS)

Open the UCEC breakdown →