BRDT

Across TCGA patient cohorts, BRDT mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRDT-associated genes across cancer lineages are 14-3-3_beta, p70-S6K_pT389, and ATM. Each is linked with BRDT in more than 2 cancer types. Because this analysis shows association rather than direction, both BRDT-to-partner and partner-to-BRDT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by BRDT-low versus BRDT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRDT→partner) and Y-score (partner→BRDT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.063	-1.673	.034	.040	3	3
UCEC	p70-S6K_pT389 →	-0.146	-1.415	.010	.040	3	3
UCEC	ATM →	-0.474	-1.893	<.001	.014	3	3
UCEC	4E-BP1 →	+0.272	+2.415	<.001	.002	3	3
LUSC	PEA-15 →	+0.334	+3.009	.006	.019	3	2
LUSC	XBP1 →	+0.237	+2.834	.036	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

14-3-3_beta by BRDT expression — UCEC

Explore this box plot interactively →