BRDT

Across TCGA cell cohorts, BRDT mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRDT-associated genes across cancer lineages are CCDC140, KCNK16, and OR1L6. Each is linked with BRDT in more than 1 cancer types. Because this analysis shows association rather than direction, both BRDT-to-partner and partner-to-BRDT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC140 grouped by BRDT-low versus BRDT-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRDT→partner) and Y-score (partner→BRDT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC140 →	+0.083	+4.643	.001	.008	3	1
LUNG_NSCLC_LUSC	KCNK16 →	+0.413	+4.643	.001	.008	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.014	+4.662	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
OVARY	SULT1C3 →	+0.192	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CCDC140 by BRDT expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →