BRD7

Across TCGA patient cohorts, BRD7 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD7-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and NF-kB-p65_pS536. Each is linked with BRD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRD7-to-partner and partner-to-BRD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by BRD7-low versus BRD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD7→partner) and Y-score (partner→BRD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.163	-2.584	.009	.010	3	2
UCEC	mTOR_pS2448 →	-0.163	-2.209	.003	.009	3	2
UCEC	NF-kB-p65_pS536 →	-0.389	-2.459	.022	.018	3	2
UCEC	PDCD4 →	-0.798	-2.662	<.001	<.001	3	2
UCEC	PKC-b-II_pS660 →	-0.242	-1.700	.019	.042	3	2
UCEC	ATM →	-0.648	-1.765	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK_pT183_Y185 by BRD7 expression — UCEC

Explore this box plot interactively →