Across TCGA patient cohorts, BRD2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,845 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BRD2-associated genes across cancer lineages are CEP152, OIP5, and RAD51AP1. Each is linked with BRD2 in more than 6 cancer types. Because this analysis shows association rather than direction, both BRD2-to-partner and partner-to-BRD2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD2→partner) and Y-score (partner→BRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEP152 →	+0.744	+0.245	.001	<.001	3	7
BRCA	OIP5 →	+0.753	+0.274	<.001	<.001	3	7
BRCA	RAD51AP1 →	+1.028	+0.305	<.001	<.001	3	7
LSCC	RFC5 →	+0.886	+0.308	<.001	<.001	3	7
UCEC	FANCE →	+0.889	+0.192	<.001	<.001	3	7
LSCC	MCM3 →	+0.932	+0.308	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,845 associations by consensus.

Exploration

BRD2 survival (RNA) · tumor vs normal (RNA) · all BRD2 data types