BRD2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BRD2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD2-associated genes across cancer lineages are ATM, ACC1, and PCNA. Each is linked with BRD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRD2-to-partner and partner-to-BRD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD2→partner) and Y-score (partner→BRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECATM →-0.405-1.362.011.03733
UCECACC1 →+0.299+2.335.020.01832
UCECPCNA →+0.187+1.700.014.04232
UCECPDK1_pS241 →+0.147+1.900.014.02832
UCECRad50 →-0.312-2.392<.001<.00132
UCECAnnexin_VII →-0.127-1.662.009.01132
Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration