Across TCGA cell cohorts, BRD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,389 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRD2-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Positive regulation of double-strand break repair, and Microtubule nucleation. Each is linked with BRD2 in more than 16 cancer types. Because this analysis shows association rather than direction, both BRD2-to-partner and partner-to-BRD2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD2→partner) and Y-score (partner→BRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.092	+1.105	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.090	+0.889	<.001	<.001	3	16
BONE	Microtubule nucleation →	+0.141	+0.870	<.001	<.001	3	16
SOFT_TISSUE	Regulation of DNA repair →	+0.070	+1.018	<.001	<.001	3	15
LARGE_INTESTINE	Negative regulation of DNA-templated transcription initiation →	+0.140	+0.988	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.083	+0.900	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,389 associations by consensus.

Exploration

BRD2 survival (RNA) · tumor vs normal (RNA) · all BRD2 data types