BRD1

Across TCGA pan-cancer cohorts, BRD1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated BRD1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BRD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BRD1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, THYM, and UCEC are the cancer types where BRD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.181	0.663	<.001	45	view →
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.962	0.615	.002	36	view →
LUAD	OS	Median	All	0.223	0.788	.002	25	view →
LGG	DFS	Median	All	0.156	0.753	<.001	6	view →
STAD	OS	Median	IV	0.052	0.541	.003	6	view →
BLCA	DFS	Median	III,IV	0.242	0.578	.028	6	view →
PRAD	DFS	Median	All	0.435	0.888	<.001	6	view →
READ	OS	Median	All	0.156	0.692	.010	3	view →
SKCM	OS	Median	II,III,IV	0.915	0.722	.024	3	view →
LUSC	DFS	Median	All	1.000	0.753	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

BRD1–HNSC (OS)

Open the HNSC breakdown →