BRD1

Across TCGA patient cohorts, BRD1 mutation is significantly associated with the RNA expression of many other genes, with 3,811 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD1-associated genes across cancer lineages are SNRNP25, LRR1, and FH. Each is linked with BRD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRD1-to-partner and partner-to-BRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRNP25 grouped by BRD1-low versus BRD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD1→partner) and Y-score (partner→BRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRNP25 →	+0.472	+3.847	.004	<.001	3	4
COAD	LRR1 →	+0.479	+3.469	.007	.002	3	4
UCEC	FH →	+0.279	+1.415	.007	.002	3	4
COAD	PPP1R8 →	+0.321	+2.700	.003	.006	3	4
UCEC	CHEK1 →	+0.405	+1.869	.004	.004	2	4
UCEC	BUB3 →	+0.392	+2.397	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,811 associations by consensus.

SNRNP25 by BRD1 expression — COAD

Explore this box plot interactively →