BRD1

Across TCGA patient cohorts, BRD1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRD1-associated genes across cancer lineages are NF2, eEF2, and MEK1. Each is linked with BRD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRD1-to-partner and partner-to-BRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by BRD1-low versus BRD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD1→partner) and Y-score (partner→BRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NF2 →	+0.201	+1.584	.048	.035	3	3
STAD	eEF2 →	+0.328	+3.000	.036	.036	3	2
UCEC	MEK1 →	+0.327	+1.523	.001	.006	3	2
COAD	PCNA →	+0.249	+2.820	.025	.035	3	2
COAD	PKC-delta_pS664 →	-0.135	-2.313	.024	.035	3	2
UCEC	JNK2 →	+0.254	+1.954	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

NF2 by BRD1 expression — SKCM

Explore this box plot interactively →