BRD1

Across TCGA cell cohorts, BRD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,832 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BRD1-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with BRD1 in more than 17 cancer types. Because this analysis shows association rather than direction, both BRD1-to-partner and partner-to-BRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by BRD1-low versus BRD1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRD1→partner) and Y-score (partner→BRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of chromosome condensation →	+0.199	+0.964	<.001	<.001	3	18
KIDNEY	Symbiont-mediated disruption of host cellular anatomical structure →	+0.177	+0.971	<.001	<.001	3	16
KIDNEY	Symbiont-mediated disruption of host anatomical structure →	+0.177	+0.971	<.001	<.001	3	16
BONE	Heterochromatin organization →	+0.084	+1.242	<.001	<.001	3	16
STOMACH	Negative regulation of brown fat cell differentiation →	+0.228	+0.860	<.001	.001	3	15
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.241	+0.870	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,832 associations by consensus.

Negative regulation of chromosome condensation by BRD1 expression — LARGE_INTESTINE

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