Across TCGA patient cohorts, BRCC3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRCC3-associated genes across cancer lineages are ASNS, Caspase-8, and eEF2. Each is linked with BRCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BRCC3-to-partner and partner-to-BRCC3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCC3→partner) and Y-score (partner→BRCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.396	+1.700	.003	.042	3	2
UCEC	Caspase-8 →	-0.211	-1.673	.025	.040	3	2
UCEC	eEF2 →	+0.432	+2.169	.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.280	-2.169	.002	.003	3	1
UCEC	ERK2 →	+0.240	+2.584	<.001	.010	3	1
UCEC	GAPDH →	+0.635	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

BRCC3 survival (RNA) · tumor vs normal (RNA) · all BRCC3 data types